I’ve been on Dupixent for nearly 3 months now, and I’d say I’m a partial responder at this point. Initially, I saw some improvement in the first few days. Some of my nodules started to shrink and the leathery skin started to disappear. Nothing had ever worked for me, so I knew this drug was a step in the right direction. Then after 6 weeks, things started to slow down and I had another flare up (likely due to another autoimmune-related condition). A spot on my cheek that had disappeared for a while had unfortunately returned. I went to my dermatologist and asked her to freeze off the leathery skin from my face and legs, which she did using cryotherapy/liquid nitrogen. Since I am on Dupixient, I noticed that my leathery skin hasn’t returned yet after the skin has been frozen off. Not a magic bullet but major progress for me. I’m hopeful again. My hope is that Dupixient works for you.

Mine took about a mont and works well for me

I'm using mupirocin to, I have ezma to and sorris to, I can't spell too good sorry but I hope you no what I mean thanks

Nothing? Wow, mine showed a drop in itching within days of the first injection. Have you talked to your dermatologist why it's not doing anything? Granted, it didn't heal lesions by themselves, but it slowed them, and using Mupirocin ointment helped them to heal, at least for me, that's how it went.

Thanks