The opening and closing sensations you're feeling in your nodules are very real and connected to how PN affects your nerves and skin. When nodules form, the nerves in and around them can become hypersensitive, causing unusual sensations like burning, stabbing, or that strange opening/closing feeling.
This is sometimes Show Full Answer
The opening and closing sensations you're feeling in your nodules are very real and connected to how PN affects your nerves and skin. When nodules form, the nerves in and around them can become hypersensitive, causing unusual sensations like burning, stabbing, or that strange opening/closing feeling.
This is sometimes called neuropathic pain — where the nerves themselves are sending pain signals even without an obvious wound. Some MyPrurigoTeam members describe it as feeling like being stabbed, or like a bruise that hurts even after a nodule appears healed. There are several approaches that may help manage these nerve sensations:
- Topical corticosteroids — reduce inflammation around the nodules, which can calm nerve irritation
- Phototherapy (light therapy) — can help settle overactive skin responses
- Immunosuppressive treatments — such as methotrexate or cyclosporine, prescribed by a dermatologist
- Biologics — newer targeted medicines that address the immune response driving PN
- Ice packs — some MyPrurigoTeam members find cold helps interrupt the pain/itch cycle
- CBD creams — a few members have reported short-term relief
It's worth noting that standard over-the-counter pain relievers often don't work well for nerve-related pain specifically.
The most important step is talking to a dermatologist about these sensations directly — nerve pain in PN can sometimes be undertreated because doctors focus mainly on the itch. Advocating for yourself on this is really important.
May 9
It was so good for me to read about how the sensations around the nodules are related to nerves. My dermatologist told me that but I had never heard of anyone else experiencing sensations until I read about it here. I worried that I was having something similar to hallucinations. I could feel things growing out of my scalp like plastic pieces and flower tops and rows of staples. It kept changing and I kept pulling it all out. Trouble was, I could never see any of it in my hand…only feel it. I thought I was losing my mind. I have to say I really think after being on Nemluvio for 3-4 months, that sensation stopped.
Very strange I know. Worst disease ever.
June 4
Hi Kendra! That sensation could be related to your nervous system. I suggest discussing this symptom with your dermatologist.
May 9
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