A new study shows that people with prurigo nodularis treated with nemolizumab (sold as Nemluvio) experienced sustained relief from intense itch and skin lesions for up to two years. The treatment was also well tolerated, with no new safety concerns reported.

What Is Nemolizumab?

Approved by the U.S. Food and Drug Administration in 2024, nemolizumab is the first and only biologic therapy approved to treat prurigo nodularis, a chronic skin condition marked by intensely itchy, thick nodules. The drug is a monoclonal antibody that targets interleukin (IL)-31, a molecule that triggers itch and skin inflammation. By blocking IL-31 signals, nemolizumab helps reduce both itch and skin damage.

Nemolizumab is given as a subcutaneous (under the skin) injection.

Study Shows Sustained Benefits at 2 Years

In an ongoing clinical trial, researchers followed more than 500 people with moderate to severe prurigo nodularis. After 100 weeks of treatment:

• More than 90 percent saw at least a four-point drop in itch levels, as measured on the Peak Pruritus Numerical Rating Scale.
• More than 70 percent were itch-free or nearly itch-free.
• At least 80 percent saw between 76 percent and 100 percent of their skin lesions heal.
• About 75 percent had clear or almost-clear skin nodules, based on clinical assessments.

Researchers noted that nemolizumab continued to be safe and effective over time, and no new side effects were seen. According to the drug’s prescribing information, the most common side effects include headache and types of eczema.

What This Means for People Living With Prurigo Nodularis

Prurigo nodularis is often difficult to manage, with few treatment options available. These new findings offer hope that nemolizumab may help provide lasting relief from some of the most disruptive symptoms — like persistent itching and visible nodules.

If you’re living with prurigo nodularis and aren’t finding relief with your current treatment, speak with your dermatologist about alternatives. Together, you can create a plan that meets your specific treatment goals.

Learn about nine treatment options available for prurigo nodularis.

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