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Real members of MyPrurigoTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I wonder how many who use a biologic are also using Rx topicals to deal with their PN and how aggressive they are in their approach.

A MyPrurigoTeam Member asked a question 💭
Phoenix, AZ

I ask because I basically declared war on my Prurigo.

Here's my regimen:
Dupixent SubQ every 6 weeks.

Daily in alternating 2-week cycles:

Two weeks of Clobetasol or Triamcinolone applied twice daily to nodes. Clobetasol is the stronger.

Two weeks of Tacrolimus applied same as steroids.

Mixed in with those is Opzelura applied to just one limb at a time.

Plus I take regular colloidal oatmeal baths and use daily skin cream.

Seems a lot but at peak, I had more than 400 nodes from my neck to… read more

November 28, 2025
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Reactions
A MyPrurigoTeam Member

Hi MArk I’m sorry you suffer so extensively that is hard for you to wear clothes. I only have three lesions and my derm told me yesterday she is not totally convinced that it is PN a and think it may be a misdiagnosis. I don’t know. I just use topical creams and she has prescribed me tape with steroids in

December 6, 2025
A MyPrurigoTeam Member

Guess that was what I was wondering: what are other people's plans. Unless one feels that is too personal it might give others ideas to improve their care regimen. That's why I share and look to see what others have shared. It's part of my ongoing research.

November 28, 2025
A MyPrurigoTeam Member

Marc, I think that whatever works for you is a plan. I have a treatment plan as well. It's important that each of us find a plan that promoted symptom relief, healing,and comfort. I'm so happy to read that you are improving.

November 28, 2025
MyPrurigoTeam

How common is it to combine biologics with prescription topicals for PN treatment?

Your aggressive treatment approach makes a lot of sense, especially given how extensive your PN was. Many dermatologists actually recommend combining systemic medications like biologics with topical treatments rather than using topicals Show Full Answer

How common is it to combine biologics with prescription topicals for PN treatment?

Your aggressive treatment approach makes a lot of sense, especially given how extensive your PN was. Many dermatologists actually recommend combining systemic medications like biologics with topical treatments rather than using topicals alone.

Topical agents for PN are often considered adjunctive therapy, best used alongside a systemic agent like your Dupixent. This is because PN is truly systemic - many people experience itch not just in the nodules but also in normal-appearing skin between them.

Your combination strategy addresses multiple aspects:
- The biologic targets systemic inflammation
- Topical steroids (Clobetasol and Triamcinolone) reduce local inflammation
- Tacrolimus (a calcineurin inhibitor) modulates immune activity in the skin
- Opzelura (the JAK inhibitor) helps older nodules heal

It's wonderful that you're seeing results - reduced itch, fewer new nodules, and healing of older lesions. The fact that you could comfortably attend a social gathering shows real progress.

Your rotating approach with the topicals is smart too, as it may help prevent issues like skin thinning from prolonged steroid use while maintaining treatment effectiveness.

November 28, 2025

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