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Real members of MyPrurigoTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I have been on dupixent 3 months and don't know what to expect but see a pattern. After the treatment I am really sick for about 3 days,

A MyPrurigoTeam Member asked a question 💭
Berea, OH

hurt all over, chills. Have any of you experienced this? And now itch, tiny sores, so tired. I don't know what to expect but not this! Any opinions appreciated! Bless you all!

March 24
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Answer Summary

Members shared mixed experiences with Dupixent for prurigo nodularis, with some finding relief from itching and nodules while others reported... Read more

Members shared mixed experiences with Dupixent for prurigo nodularis, with some finding relief from itching and nodules while others reported concerning side effects like leg and foot cramps, extreme fatigue, chills, and body aches that lasted several days after each injection. Several members emphasized the critical importance of breaking the itch-scratch cycle through distraction techniques, pimple patches to cover nodules, and supplements like N-Acetyl-Cysteine (NAC 600mg twice daily), which some found significantly reduced itching. A recurring theme was the strong community consensus that anyone experiencing severe or unusual symptoms should contact their prescribing physician immediately rather than comparing experiences online, as not everyone responds well to every medication and insurance barriers often complicate finding the right treatment.

A MyPrurigoTeam Member

Having just been hospitalized for a low potassium, I'm going to respectfully suggest that any side effects that you all are experiencing be shared with your treating physician for your protection and well being.

March 31
A MyPrurigoTeam Member

I purchased N-Acetyl-Cysteine (NAC 600mg from Amazon after you posted this recommendation. After 3 weeks, I still have the PN nodules and lesions, but less itching. I am so inclined to scratch the PN nodules -a bad habit. I tried Blenderm tape, which for me causes the PN nodules and lesions to build up fluid under rhe skin. I scratch as soon as the tape is removed. I believe stress contributes to PN.

March 27
A MyPrurigoTeam Member

I think in many cases Insurance is a big issue for people with PN. Insurance companies are not forthcoming in covering the meds that help us and the prices are not manageable. They’re then relegated to OTC products and that’s tricky.
All we can do is share our knowledge of how to manage this nightmare with affordable solutions. So very frustrating!!!!!

April 4
A MyPrurigoTeam Member

Hi Carol! I totally agree with you! I've asked Georgia many times to please contact her dermatologist. I don't understand why she hasn't done this as of yet. It's beyond concerning to me

April 2
A MyPrurigoTeam Member

Your doctor needs to address this and get you off of Dupixent. There are other options that you can use. I’m on Nemluvio and it’s working better than Dupixent.

April 2

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