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Real members of MyPrurigoTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyPrurigoTeam Member asked a question 💭
Sykesville, MD
December 23, 2025
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MyPrurigoTeam

Has anyone noticed that Nemluvio becomes less effective over time?

Actually, recent research suggests the opposite. A long-term study following people with prurigo nodularis for up to two years found that nemolizumab (Nemluvio) continued to provide sustained relief without losing effectiveness.

After 100 weeks of Show Full Answer

Has anyone noticed that Nemluvio becomes less effective over time?

Actually, recent research suggests the opposite. A long-term study following people with prurigo nodularis for up to two years found that nemolizumab (Nemluvio) continued to provide sustained relief without losing effectiveness.

After 100 weeks of treatment:
- More than 90 percent maintained at least a four-point drop in itch levels
- More than 70 percent were itch-free or nearly itch-free
- At least 80 percent saw between 76 percent and 100 percent of their skin lesions heal
- About 75 percent had clear or almost-clear skin nodules

Researchers noted that the medication remained safe and effective over time, with no new side effects emerging during the extended treatment period.

If you're experiencing reduced effectiveness, it's worth discussing with your dermatologist. Individual responses can vary, and they may want to evaluate whether other factors could be affecting your symptoms or if adjustments to your treatment plan might help.

December 23, 2025

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